If we are talking about the same Charlotte it is in NC and about 4 hours west of 95. Although the route down 81 and 77 brings you right through Charlotte but it is a bit longer than 95. It is a prettier ride because you are west of the blue ridge mountains and not as congested as 95. There are a good amount of trucks though.
I have done both multiple times Worcester to Savannah.
In my opinion depending on the day of week, 95 can be a beast with a trailer through NYC, DC, Richmond.
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