Originally Posted by S-C50Rob

Don't take an expensive guitar with you and go with a backpack style. Remember you're in front of it so wind resistance is very minor, unless you're riding for 6 hours at top speeds I don't see what damage can be done to the neck. As fat as temperature changes, if you were to put you guitar in the trunk of your car it's pretty much the same thing as having it outside. Unless you have the first car to have a heated trunk. I'm a traveling musician and have done so much winter touring (hate it!!!) and all the guitars need is a little while to warm up again once we reach our destination. And that's after 6 to 10 hours of driving with the gear in a trailer... I wouldn't stress over it, but I would take a less expensive electric guitar for 2 simple reasons. 1-smaller body 2-the fear of something happening to the guitar accidentally. Leave the good gear at home. Unless you have a gig and need your amp and other things, then just take your car. That's my 2 cents... either way, have fun riding and playing!!!

Originally Posted by grego

Even with the best case, I'd only carry cheapo guitars. Cheap to me means a guitar I could live without.

Now, how to we lug the Marshall half stack around??

Originally Posted by dfinitlydisturbd

Ditch the Marshall and get an early BassMan (same, thing Marshall ripped of the circuitry).
That said I have carried my 410 Bassman on my bike(along with two basses!) and my Twin reverb has occupied my rack a couple of times with my Strat strapped to the sissybar on the passenger seat. The 212 ain't to bad, but i wouldn't recommend the 410...that one makes handling suck much. If you have to tote an amp get a trailer, otherwise a good hard shell case and a rain cover will get your axe there intact. Heck even a good gigbag won't put any undo stress on your axe...again you want some sort of backup weather protection in case things get wet out. The only part of the guitar that sees any real wind is the headstock, If you are concerned about wind pressure causing undo stress put it in your gig bag backwards to that pressure is opposite of the pressure exerted by the strings and they'll bear the load.